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C5orf20 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8TF63 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C5orf20 |
| Epitope Specificity | 131-244/244 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. Note=Particularly on the periphery. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | C5orf20 is a intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans |
| Gene ID | 140947 |
|---|---|
| Other Names | Dendritic cell nuclear protein 1, Dendritic cell nuclear protein-1, Dendritic cell-associated nuclear protein, DCANP1 (HGNC:24459) |
| Target/Specificity | Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Not expressed in monocytes and B-cells. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | DCANP1 (HGNC:24459) |
|---|---|
| Function | Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter. |
| Cellular Location | Nucleus. Cytoplasm Note=Particularly on the periphery. Colocalizes with corticotropin- releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus. |
| Tissue Location | Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP55865
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