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UNC13B Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O14795
Clone Names 100324023
Peptide ID 100324023
Additional Information
Gene ID 10497
Other Names Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13116a was selected from the N-term region of UNC13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC13B
Synonyms UNC13
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity).
Tissue Location Expressed in kidney cortical epithelial cells and brain.
Research Areas
Citations (0)

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This gene is expressed in the kidney cortical epithelialcells and is upregulated by hyperglycemia. The encoded proteinshares a high level of similarity to the rat homolog, and contains3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemiaincreases the levels of diacylglycerol, which has been shown toinduce apoptosis in cells transfected with this gene and thuscontribute to the renal cell complications of hyperglycemia.Studies in other species also indicate a role for this protein inthe priming step of synaptic vesicle exocytosis. [provided byRefSeq].


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Goldenberg, N.M., et al. Am. J. Physiol., Cell Physiol. 297 (4), C1053-C1058 (2009) :Dimova, K., et al. Biochemistry 48(25):5908-5921(2009)Tregouet, D.A., et al. Diabetes 57(10):2843-2850(2008)Speight, P., et al. Traffic 6(10):858-865(2005)

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Cat# BP13116a
Availability: Back Order
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