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UNC13B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | O14795 |
| Other Accession | Q9Z1N9 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 180679 Da |
| Antigen Region | 1062-1091 aa |
| Gene ID | 10497 |
|---|---|
| Other Names | Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13 |
| Target/Specificity | This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UNC13B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UNC13B (HGNC:12566) |
|---|---|
| Synonyms | UNC13 |
| Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane Synapse. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity) |
| Tissue Location | Expressed in kidney cortical epithelial cells and brain. |
Provided below are standard protocols that you may find useful for product applications.
Background
UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
References
Sjoeblom T., et.al., Science 314:268-274(2006).
Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162(2007).
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