- CITATIONS: 1
|Application ||FC, WB, E|
|Calculated MW||180679 Da|
|Antigen Region||1062-1091 aa|
|Other Names||Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13|
|Target/Specificity||This UNC13B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1062-1091 amino acids from the Central region of human UNC13B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UNC13B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane Cell junction, synapse. Note=Localized to synapses Translocated to the plasma membrane in response to phorbol ester binding (By similarity).|
|Tissue Location||Expressed in kidney cortical epithelial cells and brain.|
Provided below are standard protocols that you may find useful for product applications.
UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
Sjoeblom T., et.al., Science 314:268-274(2006).
Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162(2007).
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