|Other Names||Carbohydrate sulfotransferase 9, 282-, GalNAc-4-O-sulfotransferase 2, GalNAc-4-ST2, GalNAc4ST-2, N-acetylgalactosamine-4-O-sulfotransferase 2, CHST9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13188a was selected from the N-term region of CHST9. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.|
|Cellular Location||Isoform 1: Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
Sulfate groups in carbohydrates confer highly specificfunctions on glycoproteins, glycolipids, and proteoglycans and arecritical for cell-cell interaction, signal transduction, andembryonic development. Sulfotransferases, such as CHST9, carry outsulfation of carbohydrates (Hiraoka et al., 2001 [PubMed11445554]).
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Hiraoka, N., et al. Glycobiology 11(6):495-504(2001)Kang, H.G., et al. J. Biol. Chem. 276(14):10861-10869(2001)
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