|Other Names||Acetyl-coenzyme A synthetase, cytoplasmic, Acetate--CoA ligase, Acetyl-CoA synthetase, ACS, AceCS, Acyl-CoA synthetase short-chain family member 2, Acyl-activating enzyme, ACSS2, ACAS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP13231c was selected from the Center region of ACSS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activates acetate so that it can be used for lipid synthesis or for energy generation.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic enzyme that catalyzes theactivation of acetate for use in lipid synthesis and energygeneration. The protein acts as a monomer and produces acetyl-CoAfrom acetate in a reaction that requires ATP. Expression of thisgene is regulated by sterol regulatory element-binding proteins,transcription factors that activate genes required for thesynthesis of cholesterol and unsaturated fatty acids. Alternativesplicing results in multiple transcript variants. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Yilmaz, S., et al. Genomics 96(1):57-65(2010)Ban, H.J., et al. BMC Genet. 11, 26 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Yun, M., et al. J. Nucl. Med. 50(8):1222-1228(2009)
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