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MOSPD2 Antibody (N-term ) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NHP6
Clone Names 100416045
Peptide ID 100416045
Additional Information
Other Names Motile sperm domain-containing protein 2, MOSPD2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13323a was selected from the N-term region of MOSPD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MOSPD2
Function Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
Cellular Location Cell membrane; Single-pass membrane protein
Tissue Location Highly expressed in CD14(+) monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells. EMBL; AK093075; BAC04043.1; -; mRNA EMBL; BC030641; AAH30641.1; -; mRNA EMBL; AL834345; CAD39011.1; -; mRNA CCDS; CCDS14162.1; -. [Q8NHP6-1] RefSeq; NP_001170946.1; NM_001177475.1. [Q8NHP6-2] RefSeq; NP_689794.1; NM_152581.3. [Q8NHP6-1] UniGene; Hs.744919; - ProteinModelPortal; Q8NHP6; - SMR; Q8NHP6; - BioGrid; 127702; 30 IntAct; Q8NHP6; 6 STRING; 9606.ENSP00000369860; - iPTMnet; Q8NHP6; - PhosphoSitePlus; Q8NHP6; - BioMuta; MOSPD2; - DMDM; 67461057; - EPD; Q8NHP6; - jPOST; Q8NHP6; - MaxQB; Q8NHP6; - PaxDb; Q8NHP6; - PeptideAtlas; Q8NHP6; - PRIDE; Q8NHP6; - ProteomicsDB; 73729; - ProteomicsDB; 73730; -. [Q8NHP6-2] DNASU; 158747; - Ensembl; ENST00000380492; ENSP00000369860; ENSG00000130150. [Q8NHP6-1] GeneID; 158747; - KEGG; hsa:158747; - UCSC; uc004cwi.4; human. [Q8NHP6-1] CTD; 158747; - EuPathDB; HostDB:ENSG00000130150.11; - GeneCards; MOSPD2; - HGNC; HGNC:28381; MOSPD2 HPA; HPA003334; - neXtProt; NX_Q8NHP6; - OpenTargets; ENSG00000130150; - PharmGKB; PA134898878; - eggNOG; KOG1470; Eukaryota eggNOG; ENOG410Y3Q0; LUCA GeneTree; ENSGT00390000016713; - HOGENOM; HOG000007082; - HOVERGEN; HBG056024; - InParanoid; Q8NHP6; - OMA; IFEMPWI; - OrthoDB; 457524at2759; - PhylomeDB; Q8NHP6; - TreeFam; TF351054; - Reactome; R-HSA-6798695; Neutrophil degranulation ChiTaRS; MOSPD2; human GenomeRNAi; 158747; - PMAP-CutDB; Q8NHP6; - PRO; PR:Q8NHP6; - Proteomes; UP000005640; Chromosome X Bgee; ENSG00000130150; Expressed in 213 organ(s), highest expression level in corpus callosum ExpressionAtlas; Q8NHP6; baseline and differential Genevisible; Q8NHP6; HS GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB GO; GO:0016020; C:membrane; HDA:UniProtKB GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0035579; C:specific granule membrane; TAS:Reactome GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IDA:UniProtKB CDD; cd00170; SEC14; 1 Gene3D; 2.60.40.10; -; 1 Gene3D; 3.40.525.10; -; 1 InterPro; IPR001251; CRAL-TRIO_dom InterPro; IPR036865; CRAL-TRIO_dom_sf InterPro; IPR036273; CRAL/TRIO_N_dom_sf InterPro; IPR013783; Ig-like_fold InterPro; IPR000535; MSP_dom InterPro; IPR008962; PapD-like_sf Pfam; PF00650; CRAL_TRIO; 1 Pfam; PF00635; Motile_Sperm; 1 SMART; SM00516; SEC14; 1 SUPFAM; SSF46938; SSF46938; 1 SUPFAM; SSF49354; SSF49354; 1 SUPFAM; SSF52087; SSF52087; 1 PROSITE; PS50191; CRAL_TRIO; 1 PROSITE; PS50202; MSP; 1 1: Evidence at protein level; Alternative splicing; Cell membrane; Chemotaxis; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 518 Motile sperm domain-containing protein 2 /FTId=PRO_0000213463 TRANSMEM 497 517 Helical. DOMAIN 82 239 CRAL-TRIO. {ECO:0000255|PROSITE- ProRule:PRU00056} DOMAIN 327 445 MSP. {ECO:0000255|PROSITE- ProRule:PRU00132} VAR_SEQ 1 63 Missing (in isoform 2) /FTId=VSP_014046 VARIANT 240 240 S -> N (in dbSNP:rs35164803) /FTId=VAR_034109 SEQUENCE 518 AA; 59746 MW; 6CC5920CF3B251E2 CRC64; MAENHAQNKA KLISETRRRF EAEYVTDKSD KYDARDVERL QQDDNWVESY LSWRHNIVDE TLKMLDESFQ WRKEISVNDL NESSIPRWLL EIGVIYLHGY DKEGNKLFWI RVKYHVKDQK TILDKKKLIA FWLERYAKRE NGKPVTVMFD LSETGINSID MDFVRFIINC FKVYYPKYLS KIVIFDMPWL MNAAFKIVKT WLGPEAVSLL KFTSKNEVQD YVSVEYLPPH MGGTDPFKYS YPPLVDDDFQ TPLCENGPIT SEDETSSKED IESDGKETLE TISNEEQTPL LKKINPTEST SKAEENEKVD SKVKAFKKPL SVFKGPLLHI SPAEELYFGS TESGEKKTLI VLTNVTKNIV AFKVRTTAPE KYRVKPSNSS CDPGASVDIV VSPHGGLTVS AQDRFLIMAA EMEQSSGTGP AELTQFWKEV PRNKVMEHRL RCHTVESSKP NTLTLKDNAF NMSDKTSEDI CLQLSRLLES NRKLEDQVQR CIWFQQLLLS LTMLLLAFVT SFFYLLYS
Research Areas
Citations (0)

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Background

The specific function of this protein remains unknown.

References

Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)

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Cat# BP13323a
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