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PRCP Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P42785
Clone Names 100324124
Peptide ID 100324124
Additional Information
Gene ID 5547
Other Names Lysosomal Pro-X carboxypeptidase, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase, PRCP, PRCP, PCP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP13385a was selected from the N-term region of PRCP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PCP
Function Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Cellular Location Lysosome.
Tissue Location Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney
Research Areas
Citations (0)

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The protein encoded by this gene is a lysosomalprolylcarboxypeptidase, which cleaves C-terminal amino acids linkedto proline in peptides such as angiotension II, III anddes-Arg9-bradykinin. The cleavage occurs at acidic pH, but theenzyme activity is retained with some substrates at neutral pH.This enzyme has been shown to be an activator of the cellmatrix-associated prekallikrein. The importance of angiotension II,one of the substrates of this enzyme, in regulating blood pressureand electrolyte balance suggests that this gene may be related toessential hypertension. Alternatively spliced transcript variantsencoding distinct isoforms have been observed. [provided byRefSeq].


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zhao, X., et al. Proteomics 10(15):2882-2886(2010)Abeywickrema, P.D., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 6), 702-705 (2010) :Soisson, S.M., et al. BMC Struct. Biol. 10, 16 (2010) :Zhang, Y., et al. Chin. Med. J. 122(20):2461-2465(2009)

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Cat# BP13385a
Availability: Back Order
Bulk Size
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