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PRCP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P42785 |
| Other Accession | NP_005031.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55800 Da |
| Antigen Region | 114-143 aa |
| Gene ID | 5547 |
|---|---|
| Other Names | Lysosomal Pro-X carboxypeptidase, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase, PRCP, PRCP, PCP |
| Target/Specificity | This PRCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human PRCP. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRCP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRCP |
|---|---|
| Synonyms | PCP |
| Function | Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. |
| Cellular Location | Lysosome. |
| Tissue Location | Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Zhao, X., et al. Proteomics 10(15):2882-2886(2010)
Abeywickrema, P.D., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 6), 702-705 (2010) :
Soisson, S.M., et al. BMC Struct. Biol. 10, 16 (2010) :
Zhang, Y., et al. Chin. Med. J. 122(20):2461-2465(2009)
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