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SFTPA1B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IWL2 |
|---|---|
| Clone Names | 100525095 |
| Gene ID | 653509 |
|---|---|
| Other Names | Pulmonary surfactant-associated protein A1, PSP-A, PSPA, SP-A, SP-A1, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4, SFTPA1, COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SFTPA1 |
|---|---|
| Synonyms | COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B |
| Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (By similarity). |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a lung surfactant protein that is amember of a subfamily of C-type lectins called collectins. Theencoded protein binds specific carbohydrate moieties found onlipids and on the surface of microorganisms. This protein plays anessential role in surfactant homeostasis and in the defense againstrespiratory pathogens. Mutations in this gene are associated withidiopathic pulmonary fibrosis. Alternate splicing results inmultiple transcript variants.
References
Silveyra, P., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L523-L534 (2010) :Liu, D.Y., et al. Zhongguo Dang Dai Er Ke Za Zhi 12(6):444-446(2010)Liu, J., et al. Tohoku J. Exp. Med. 221(1):35-42(2010)Berg, T., et al. Biochim. Biophys. Acta 1543(1):159-173(2000)Childs, R.A., et al. J. Biol. Chem. 267(14):9972-9979(1992)
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