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FKBP1B Antibody (N-term E6) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P68106 |
|---|---|
| Clone Names | 80612119 |
| Gene ID | 2281 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 126 kDa FK506-binding protein, 126 kDa FKBP, FKBP-126, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP126, Rotamase, h-FKBP-12, FKBP1B, FKBP126, FKBP1L, FKBP9, OTK4 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7868a was selected from the N-term region of human FKBP1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FKBP1B (HGNC:3712) |
|---|---|
| Function | Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Cellular Location | Cytoplasm. Sarcoplasmic reticulum |
| Tissue Location | Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FKBP1B is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. The protein is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.
References
Arakawa H., Nagase H.Biochem. Biophys. Res. Commun. 200:836-843(1994) Lam E., Martin M.M., Timerman A.P.Biol. Chem. 270:26511-26522(1995)Deivanayagam C.C., Carson M.Acta Crystallogr. D 56:266-271(2000)
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