FKBP1B Antibody (N-term E6)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| IF, WB, E |
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Primary Accession | P68106 |
Other Accession | P97534, Q8HYX6, Q9Z2I2, P68107, P62943, P26883, P62942, P18203 |
Reactivity | Human, Mouse |
Predicted | Bovine, Rabbit, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 11783 Da |
Antigen Region | 1-30 aa |
Gene ID | 2281 |
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Other Names | Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 126 kDa FK506-binding protein, 126 kDa FKBP, FKBP-126, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP126, Rotamase, h-FKBP-12, FKBP1B, FKBP126, FKBP1L, FKBP9, OTK4 |
Target/Specificity | This FKBP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FKBP1B. |
Dilution | IF~~1:10~50 WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FKBP1B Antibody (N-term E6) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FKBP1B (HGNC:3712) |
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Function | Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
Cellular Location | Cytoplasm. Sarcoplasmic reticulum |
Tissue Location | Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus. |

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Provided below are standard protocols that you may find useful for product applications.
Background
FKBP1B is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. The protein is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle.
References
Arakawa H., Nagase H.Biochem. Biophys. Res. Commun. 200:836-843(1994)
Lam E., Martin M.M., Timerman A.P.Biol. Chem. 270:26511-26522(1995)
Deivanayagam C.C., Carson M.Acta Crystallogr. D 56:266-271(2000)

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