|Other Names||Phytanoyl-CoA dioxygenase, peroxisomal, Phytanic acid oxidase, Phytanoyl-CoA alpha-hydroxylase, PhyH, PHYH, PAHX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8711a was selected from the N-term region of human PHYH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the 2-hydroxylation of not only racemic phytanoyl- CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (PubMed:9326939, PubMed:10744784, PubMed:12031666, PubMed:12923223). Does not hydroxylate long and very long straight chain acyl-CoAs or 2- methyl- and 4-methyl-branched acyl-CoAs (PubMed:10744784, PubMed:12923223).|
|Tissue Location||Expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
PHYH2 catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.
Foulon,V., et.al., J. Biol. Chem. 280 (11), 9802-9812 (2005)Kikuchi,M., et.al., J. Biol. Chem. 279 (1), 421-428 (2004)
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