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UNC13B Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14795
Clone Names 90723131
Additional Information
Gene ID 10497
Other Names Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8905c was selected from the Center region of human UNC13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC13B (HGNC:12566)
Synonyms UNC13
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane Synapse. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity)
Tissue Location Expressed in kidney cortical epithelial cells and brain.
Research Areas
Citations (0)
citation

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Background

UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).

References

Sjoeblom T., et.al., Science 314:268-274(2006).Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162(2007).

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$ 277.78
Cat# BP8905c
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Availability: 2 weeks
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