|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM-TS 18, ADAM-TS18, ADAMTS-18, 3424-, ADAMTS18, ADAMTS21|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8906b was selected from the C-term region of human ADAMTS18. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium|
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Provided below are standard protocols that you may find useful for product applications.
ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor.
Zeng,W., et.al., Biochim. Biophys. Acta 1760 (3), 517-524 (2006)Jin,H., et.al., Oncogene 26 (53), 7490-7498 (2007)
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