ADAMTS18 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8TE60 |
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Clone Names | 90723135 |
Gene ID | 170692 |
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Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 18, ADAM-TS 18, ADAM-TS18, ADAMTS-18, 3424-, ADAMTS18, ADAMTS21 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8906b was selected from the C-term region of human ADAMTS18. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ADAMTS18 |
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Synonyms | ADAMTS21 |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor.
References
Zeng,W., et.al., Biochim. Biophys. Acta 1760 (3), 517-524 (2006)Jin,H., et.al., Oncogene 26 (53), 7490-7498 (2007)
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