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GNB1L Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BYB4 |
|---|---|
| Clone Names | 90415084 |
| Gene ID | 54584 |
|---|---|
| Other Names | Guanine nucleotide-binding protein subunit beta-like protein 1, G protein subunit beta-like protein 1, DGCRK3, WD repeat-containing protein 14, WD40 repeat-containing protein deleted in VCFS, WDVCF, GNB1L, GY2, KIAA1645, WDR14 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8967c was selected from the Center region of human GNB1L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GNB1L (HGNC:4397) |
|---|---|
| Synonyms | GY2, KIAA1645, WDR14 |
| Function | Acts as a critical regulator of DNA damage response (DDR) signaling via specifically regulating phosphatidylinositol 3-kinase- related protein kinase (PIKK) family proteins. |
| Cellular Location | Cytoplasm. Nucleus. Note=Localizes mainly in cytosol and to a lesser extent in the nucleus. |
| Tissue Location | Ubiquitous. Highly expressed in heart, liver, skeletal muscle, kidney, spleen, thymus and pancreas. Detected at low levels in lung, placenta and brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GNB1L is a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart.
References
Funke,B., et.al., Genomics 73 (3), 264-271 (2001)Collins,J.E., et.al., Genome Biol. 5 (10), R84 (2004)
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