|Other Names||Coiled-coil domain-containing protein 85B, Hepatitis delta antigen-interacting protein A, Delta-interacting protein A, CCDC85B, DIPA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9120c was selected from the Center region of human DIPA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, adherens junction|
|Tissue Location||Widely expressed including liver.|
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Provided below are standard protocols that you may find useful for product applications.
DIPA functions as a transcriptional repressor. It may inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. It may function in adipocyte differentiation, negatively regulating mitotic clonal expansion.
Bezy,O., et.al., J. Biol. Chem. 280 (12), 11432-11438 (2005)Du,X.,et.al., Exp. Mol. Pathol. 81 (3), 184-190 (2006)
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