|Application ||FC, WB, IHC-P, E|
|Calculated MW||22091 Da|
|Antigen Region||69-96 aa|
|Other Names||Coiled-coil domain-containing protein 85B, Hepatitis delta antigen-interacting protein A, Delta-interacting protein A, CCDC85B, DIPA|
|Target/Specificity||This DIPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-96 amino acids from the Central region of human DIPA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DIPA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, adherens junction|
|Tissue Location||Widely expressed including liver.|
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Provided below are standard protocols that you may find useful for product applications.
DIPA functions as a transcriptional repressor. It may inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. It may function in adipocyte differentiation, negatively regulating mitotic clonal expansion.
Bezy,O., et.al., J. Biol. Chem. 280 (12), 11432-11438 (2005)
Du,X.,et.al., Exp. Mol. Pathol. 81 (3), 184-190 (2006)
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