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DIPA Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, IHC-P, E |
|---|---|
| Primary Accession | Q15834 |
| Other Accession | Q6PDY0 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22091 Da |
| Antigen Region | 69-96 aa |
| Gene ID | 11007 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 85B, Hepatitis delta antigen-interacting protein A, Delta-interacting protein A, CCDC85B, DIPA |
| Target/Specificity | This DIPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-96 amino acids from the Central region of human DIPA. |
| Dilution | FC~~1:10~50 WB~~1:1000 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DIPA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCDC85B |
|---|---|
| Synonyms | DIPA |
| Function | Functions as a transcriptional repressor (PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, adherens junction |
| Tissue Location | Widely expressed including liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
DIPA functions as a transcriptional repressor. It may inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. It may function in adipocyte differentiation, negatively regulating mitotic clonal expansion.
References
Bezy,O., et.al., J. Biol. Chem. 280 (12), 11432-11438 (2005)
Du,X.,et.al., Exp. Mol. Pathol. 81 (3), 184-190 (2006)
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