|Other Names||Forkhead box protein L1, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7, FREAC-7, FOXL1, FKHL11, FREAC7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9211c was selected from the Center region of human FOXL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors (By similarity).|
|Cellular Location||Nucleus. EMBL; AF315075; AAG40312.1; -; Genomic_DNA EMBL; AC009108; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC117226; AAI17227.1; -; mRNA EMBL; U13225; AAA92042.1; -; Genomic_DNA CCDS; CCDS10959.1; - PIR; S51630; S51630 RefSeq; NP_005241.1; NM_005250.2 SMR; Q12952; - BioGRID; 108589; 125 IntAct; Q12952; 117 MINT; Q12952; - STRING; 9606.ENSP00000326272; - iPTMnet; Q12952; - PhosphoSitePlus; Q12952; - BioMuta; FOXL1; - DMDM; 13638268; - jPOST; Q12952; - MassIVE; Q12952; - PaxDb; Q12952; - PeptideAtlas; Q12952; - PRIDE; Q12952; - ProteomicsDB; 59047; - Antibodypedia; 17198; 454 antibodies Ensembl; ENST00000320241; ENSP00000326272; ENSG00000176678 GeneID; 2300; - KEGG; hsa:2300; - UCSC; uc002fjr.4; human CTD; 2300; - DisGeNET; 2300; - EuPathDB; HostDB:ENSG00000176678.5; - GeneCards; FOXL1; - HGNC; HGNC:3817; FOXL1 HPA; ENSG00000176678; Tissue enhanced (gallbladder) MIM; 603252; gene neXtProt; NX_Q12952; - OpenTargets; ENSG00000176678; - PharmGKB; PA28234; - eggNOG; KOG2294; Eukaryota eggNOG; COG5025; LUCA GeneTree; ENSGT00940000162251; - HOGENOM; CLU_052451_0_0_1; - InParanoid; Q12952; - KO; K09405; - OMA; PLHWPGT; - OrthoDB; 1270467at2759; - PhylomeDB; Q12952; - TreeFam; TF316127; - SignaLink; Q12952; - BioGRID-ORCS; 2300; 2 hits in 810 CRISPR screens GenomeRNAi; 2300; - Pharos; Q12952; Tbio PRO; PR:Q12952; - Proteomes; UP000005640; Chromosome 16 RNAct; Q12952; protein Bgee; ENSG00000176678; Expressed in left coronary artery and 101 other tissues ExpressionAtlas; Q12952; baseline and differential Genevisible; Q12952; HS GO; GO:0000790; C:nuclear chromatin; ISA:NTNU_SB GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0003677; F:DNA binding; IDA:MGI GO; GO:0008301; F:DNA binding, bending; NAS:UniProtKB GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central GO; GO:0030154; P:cell differentiation; IBA:GO_Central GO; GO:0007507; P:heart development; IMP:DFLAT GO; GO:0007275; P:multicellular organism development; NAS:UniProtKB GO; GO:0061146; P:Peyer's patch morphogenesis; IEA:Ensembl GO; GO:0030166; P:proteoglycan biosynthetic process; ISS:UniProtKB GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central GO; GO:0030111; P:regulation of Wnt signaling pathway; ISS:UniProtKB GO; GO:0007495; P:visceral mesoderm-endoderm interaction involved in midgut development; ISS:UniProtKB CDD; cd00059; FH; 1 Gene3D; 220.127.116.11; -; 1 InterPro; IPR001766; Fork_head_dom InterPro; IPR018122; TF_fork_head_CS_1 InterPro; IPR030456; TF_fork_head_CS_2 InterPro; IPR036388; WH-like_DNA-bd_sf InterPro; IPR036390; WH_DNA-bd_sf Pfam; PF00250; Forkhead; 1 PRINTS; PR00053; FORKHEAD SMART; SM00339; FH; 1 SUPFAM; SSF46785; SSF46785; 1 PROSITE; PS00657; FORK_HEAD_1; 1 PROSITE; PS00658; FORK_HEAD_2; 1 PROSITE; PS50039; FORK_HEAD_3; 1 2: Evidence at transcript level; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1..345 /note="Forkhead box protein L1" /id="PRO_0000091859" DNA_BIND 48..139 /note="Fork-head" /evidence="ECO:0000255|PROSITE-ProRule:PRU00089" SEQUENCE 345 AA; 36490 MW; 015D86B57DF3BBC6 CRC64; MSHLFDPRLP ALAASPMLYL YGPERPGLPL AFAPAAALAA SGRAETPQKP PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNDCFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPGPG APEAKRPRAE THQRSAEAQP EAGSGAGGSG PAISRLQAAP AGPSPLLDGP SPPAPLHWPG TASPNEDAGD AAQGAAAVAV GQAARTGDGP GSPLRPASRS SPKSSDKSKS FSIDSILAGK QGQKPPSGDE LLGGAKPGPG GRLGASLLAA SSSLRPPFNA SLMLDPHVQG GFYQLGIPFL SYFPLQVPDT VLHFQ|
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Provided below are standard protocols that you may find useful for product applications.
The forkhead domain is a 100-amino acid monomeric DNA binding motif originally identified as a region of homology between the Drosophila forkhead protein and rat HNF3. Pierrou et al. (1994) identified 7 human genes containing forkhead domains and designated them forkhead related activators (FREAC) 1 through 7.
Rivadeneira,F., et.al., Nat. Genet. 41 (11), 1199-1206 (2009)Ferrell,R.E., et.al., Lymphat Res Biol 6 (2), 69-76 (2008)Hassel,S., et.al., Proteomics 4 (5), 1346-1358 (2004)
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