|Other Names||Tetraspanin-5, Tspan-5, Tetraspan NET-4, Transmembrane 4 superfamily member 9, TSPAN5, TM4SF9|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9223b was selected from the C-term region of human TSPAN5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
Berditchevski,F. J. Cell. Sci. 114 (PT 23), 4143-4151 (2001)Serru,V., et.al., Biochim. Biophys. Acta 1478 (1), 159-163 (2000)
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