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TSPAN5 / NET-4 Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P62079 |
| Other Accession | NP_005714.2, 10098, 56224 (mouse), 362048 (rat) |
| Reactivity | Human, Mouse, Rat |
| Predicted | Pig, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 30337 Da |
| Gene ID | 10098 |
|---|---|
| Other Names | Tetraspanin-5, Tspan-5, Tetraspan NET-4, Transmembrane 4 superfamily member 9, TSPAN5, TM4SF9 |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSPAN5 / NET-4 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSPAN5 (HGNC:17753) |
|---|---|
| Synonyms | TM4SF9 |
| Function | Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:28600292, PubMed:37516108). Promotes ADAM10-mediated cleavage of CD44 (PubMed:26686862). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (PubMed:28600292). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Sequences and expression of six new members of the tetraspanin/TM4SF family. Todd SC, Doctor VS, Levy S. Biochim Biophys Acta. 1998 Jul 30;1399(1):101-4. PMID: 9714763
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