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GFPT2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O94808
Clone Names 90723182
Additional Information
Other Names Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2, D-fructose-6-phosphate amidotransferase 2, Glutamine:fructose-6-phosphate amidotransferase 2, GFAT 2, GFAT2, Hexosephosphate aminotransferase 2, GFPT2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9282c was selected from the Center region of human GFPT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GFPT2
Function Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Tissue Location Highest levels of expression in heart, placenta, and spinal cord EMBL; AB016789; BAA74731.1; -; mRNA EMBL; BT009818; AAP88820.1; -; mRNA EMBL; BC000012; AAH00012.1; -; mRNA CCDS; CCDS43411.1; - RefSeq; NP_005101.1; NM_005110.3 SMR; O94808; - BioGRID; 115270; 36 IntAct; O94808; 11 STRING; 9606.ENSP00000253778; - DrugBank; DB00130; L-Glutamine MEROPS; C44.972; - iPTMnet; O94808; - PhosphoSitePlus; O94808; - BioMuta; GFPT2; - EPD; O94808; - jPOST; O94808; - MassIVE; O94808; - MaxQB; O94808; - PaxDb; O94808; - PeptideAtlas; O94808; - PRIDE; O94808; - ProteomicsDB; 50448; - Antibodypedia; 29588; 189 antibodies DNASU; 9945; - Ensembl; ENST00000253778; ENSP00000253778; ENSG00000131459 GeneID; 9945; - KEGG; hsa:9945; - UCSC; uc003mlw.2; human CTD; 9945; - DisGeNET; 9945; - EuPathDB; HostDB:ENSG00000131459.12; - GeneCards; GFPT2; - HGNC; HGNC:4242; GFPT2 HPA; ENSG00000131459; Tissue enhanced (adipose) MIM; 603865; gene neXtProt; NX_O94808; - OpenTargets; ENSG00000131459; - PharmGKB; PA28652; - eggNOG; KOG1268; Eukaryota eggNOG; COG0449; LUCA GeneTree; ENSGT00940000156413; - HOGENOM; CLU_012520_5_2_1; - InParanoid; O94808; - KO; K00820; - OMA; TSYYSGC; - OrthoDB; 262871at2759; - PhylomeDB; O94808; - TreeFam; TF300864; - Reactome; R-HSA-446210; Synthesis of UDP-N-acetyl-glucosamine UniPathway; UPA00113; UER00528 BioGRID-ORCS; 9945; 1 hit in 786 CRISPR screens ChiTaRS; GFPT2; human GenomeRNAi; 9945; - Pharos; O94808; Tbio PRO; PR:O94808; - Proteomes; UP000005640; Chromosome 5 RNAct; O94808; protein Bgee; ENSG00000131459; Expressed in layer of synovial tissue and 193 other tissues ExpressionAtlas; O94808; baseline and differential Genevisible; O94808; HS GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IBA:GO_Central GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl GO; GO:0006112; P:energy reserve metabolic process; TAS:ProtInc GO; GO:0006002; P:fructose 6-phosphate metabolic process; IBA:GO_Central GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; TAS:Reactome GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IBA:GO_Central CDD; cd05008; SIS_GlmS_GlmD_1; 1 CDD; cd05009; SIS_GlmS_GlmD_2; 1 InterPro; IPR017932; GATase_2_dom InterPro; IPR035466; GlmS/AgaS_SIS InterPro; IPR035490; GlmS/FrlB_SIS InterPro; IPR005855; GlmS_trans InterPro; IPR029055; Ntn_hydrolases_N InterPro; IPR001347; SIS Pfam; PF01380; SIS; 2 SUPFAM; SSF56235; SSF56235; 1 TIGRFAMs; TIGR01135; glmS; 1 PROSITE; PS51278; GATASE_TYPE_2; 1 PROSITE; PS51464; SIS; 2 1: Evidence at protein level; Aminotransferase; Glutamine amidotransferase; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transferase INIT_MET 1 /note="Removed" /evidence="ECO:0000250" CHAIN 2..682 /note="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2" /id="PRO_0000135283" DOMAIN 2..288 /note="Glutamine amidotransferase type-2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00609" DOMAIN 360..499 /note="SIS 1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00797" DOMAIN 531..672 /note="SIS 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00797" REGION 377..378 /note="Substrate-binding" /evidence="ECO:0000250|UniProtKB:Q06210" REGION 422..424 /note="Substrate-binding" /evidence="ECO:0000250|UniProtKB:Q06210" ACT_SITE 2 /note="For GATase activity" /evidence="ECO:0000250|UniProtKB:P14742" BINDING 427 /note="Substrate" /evidence="ECO:0000250|UniProtKB:Q06210" BINDING 578 /note="Substrate" /evidence="ECO:0000250|UniProtKB:Q06210" MOD_RES 244 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:23186163" VARIANT 471 /note="I -> V (in dbSNP:rs2303007)" /evidence="ECO:0000269|Ref.2" /id="VAR_013311" SEQUENCE 682 AA; 76931 MW; A090D75526F3192B CRC64; MCGIFAYMNY RVPRTRKEIF ETLIKGLQRL EYRGYDSAGV AIDGNNHEVK ERHIQLVKKR GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPS AVNSHPQRSD KGNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSVH YPGEAVATRR GSPLLIGVRS KYKLSTEQIP ILYRTCTLEN VKNICKTRMK RLDSSACLHA VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAS DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR GALTVGVTNT VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL QNRRQEIIRG LRSLPELIKE VLSLEEKIHD LALELYTQRS LLVMGRGYNY ATCLEGALKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE
Research Areas
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Background

GFPT2 controls the flux of glucose into the hexosamine pathway. This protein most likely involved in regulating the availability of precursors for N-and O-linked glycosylation of proteins.

References

Edwards,T.L., et.al., Ann. Hum. Genet. 74 (2), 97-109 (2010)Prasad,P., et.al., BMC Med. Genet. 11, 52 (2010)Srinivasan,V., et.al., Clin. Biochem. 40 (13-14), 952-957 (2007)

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$ 277.78
Cat# BP9282c
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