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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GFPT2 Antibody (Center)   

GFPT2 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GFPT2 Antibody (Center) AP9282c
    Western blot analysis of GFPT2 Antibody (Center) (Cat. #AP9282c) in A2058, K562 cell line lysates (35ug/lane). GFPT2 (arrow) was detected using the purified Pab.
  • IHC-P - GFPT2 Antibody (Center) AP9282c
    GFPT2 Antibody (Center) (Cat. #AP9282c) IHC analysis in formalin fixed and paraffin embedded human skin followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GFPT2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - GFPT2 Antibody (Center) AP9282c
    GFPT2 Antibody (Center) (Cat. #AP9282c) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O94808
Other Accession Q4KMC4, Q9Z2Z9, Q08DQ2
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 175-201 aa
Additional Information
Other Names Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2, D-fructose-6-phosphate amidotransferase 2, Glutamine:fructose-6-phosphate amidotransferase 2, GFAT 2, GFAT2, Hexosephosphate aminotransferase 2, GFPT2
Target/Specificity This GFPT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-201 amino acids from the Central region of human GFPT2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGFPT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GFPT2
Function Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Tissue Location Highest levels of expression in heart, placenta, and spinal cord EMBL; AB016789; BAA74731.1; -; mRNA EMBL; BT009818; AAP88820.1; -; mRNA EMBL; BC000012; AAH00012.1; -; mRNA CCDS; CCDS43411.1; - RefSeq; NP_005101.1; NM_005110.3 SMR; O94808; - BioGRID; 115270; 37 IntAct; O94808; 11 STRING; 9606.ENSP00000253778; - DrugBank; DB00130; L-Glutamine MEROPS; C44.972; - iPTMnet; O94808; - PhosphoSitePlus; O94808; - BioMuta; GFPT2; - EPD; O94808; - jPOST; O94808; - MassIVE; O94808; - MaxQB; O94808; - PaxDb; O94808; - PeptideAtlas; O94808; - PRIDE; O94808; - ProteomicsDB; 50448; - Antibodypedia; 29588; 190 antibodies DNASU; 9945; - Ensembl; ENST00000253778; ENSP00000253778; ENSG00000131459 GeneID; 9945; - KEGG; hsa:9945; - UCSC; uc003mlw.2; human CTD; 9945; - DisGeNET; 9945; - EuPathDB; HostDB:ENSG00000131459.12; - GeneCards; GFPT2; - HGNC; HGNC:4242; GFPT2 HPA; ENSG00000131459; Tissue enhanced (adipose) MIM; 603865; gene neXtProt; NX_O94808; - OpenTargets; ENSG00000131459; - PharmGKB; PA28652; - eggNOG; KOG1268; Eukaryota GeneTree; ENSGT00940000156413; - HOGENOM; CLU_012520_5_2_1; - InParanoid; O94808; - KO; K00820; - OMA; TSYYSGC; - OrthoDB; 262871at2759; - PhylomeDB; O94808; - TreeFam; TF300864; - PathwayCommons; O94808; - Reactome; R-HSA-446210; Synthesis of UDP-N-acetyl-glucosamine UniPathway; UPA00113; UER00528 BioGRID-ORCS; 9945; 2 hits in 867 CRISPR screens ChiTaRS; GFPT2; human GenomeRNAi; 9945; - Pharos; O94808; Tbio PRO; PR:O94808; - Proteomes; UP000005640; Chromosome 5 RNAct; O94808; protein Bgee; ENSG00000131459; Expressed in layer of synovial tissue and 206 other tissues ExpressionAtlas; O94808; baseline and differential Genevisible; O94808; HS GO; GO:0005829; C:cytosol; TAS:Reactome GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IBA:GO_Central GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl GO; GO:0006112; P:energy reserve metabolic process; TAS:ProtInc GO; GO:0006002; P:fructose 6-phosphate metabolic process; IBA:GO_Central GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; TAS:Reactome GO; GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IBA:GO_Central CDD; cd05008; SIS_GlmS_GlmD_1; 1 CDD; cd05009; SIS_GlmS_GlmD_2; 1 InterPro; IPR017932; GATase_2_dom InterPro; IPR035466; GlmS/AgaS_SIS InterPro; IPR035490; GlmS/FrlB_SIS InterPro; IPR005855; GlmS_trans InterPro; IPR029055; Ntn_hydrolases_N InterPro; IPR001347; SIS Pfam; PF01380; SIS; 2 SUPFAM; SSF56235; SSF56235; 1 TIGRFAMs; TIGR01135; glmS; 1 PROSITE; PS51278; GATASE_TYPE_2; 1 PROSITE; PS51464; SIS; 2 1: Evidence at protein level; Aminotransferase; Glutamine amidotransferase; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transferase INIT_MET 1 /note="Removed" /evidence="ECO:0000250" CHAIN 2..682 /note="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2" /id="PRO_0000135283" DOMAIN 2..288 /note="Glutamine amidotransferase type-2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00609" DOMAIN 360..499 /note="SIS 1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00797" DOMAIN 531..672 /note="SIS 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00797" REGION 377..378 /note="Substrate-binding" /evidence="ECO:0000250|UniProtKB:Q06210" REGION 422..424 /note="Substrate-binding" /evidence="ECO:0000250|UniProtKB:Q06210" ACT_SITE 2 /note="For GATase activity" /evidence="ECO:0000250|UniProtKB:P14742" BINDING 427 /note="Substrate" /evidence="ECO:0000250|UniProtKB:Q06210" BINDING 578 /note="Substrate" /evidence="ECO:0000250|UniProtKB:Q06210" MOD_RES 244 /note="Phosphoserine" /evidence="ECO:0000244|PubMed:23186163" VARIANT 471 /note="I -> V (in dbSNP:rs2303007)" /evidence="ECO:0000269|Ref.2" /id="VAR_013311" SEQUENCE 682 AA; 76931 MW; A090D75526F3192B CRC64; MCGIFAYMNY RVPRTRKEIF ETLIKGLQRL EYRGYDSAGV AIDGNNHEVK ERHIQLVKKR GKVKALDEEL YKQDSMDLKV EFETHFGIAH TRWATHGVPS AVNSHPQRSD KGNEFVVIHN GIITNYKDLR KFLESKGYEF ESETDTETIA KLIKYVFDNR ETEDITFSTL VERVIQQLEG AFALVFKSVH YPGEAVATRR GSPLLIGVRS KYKLSTEQIP ILYRTCTLEN VKNICKTRMK RLDSSACLHA VGDKAVEFFF ASDASAIIEH TNRVIFLEDD DIAAVADGKL SIHRVKRSAS DDPSRAIQTL QMELQQIMKG NFSAFMQKEI FEQPESVFNT MRGRVNFETN TVLLGGLKDH LKEIRRCRRL IVIGCGTSYH AAVATRQVLE ELTELPVMVE LASDFLDRNT PVFRDDVCFF ISQSGETADT LLALRYCKDR GALTVGVTNT VGSSISRETD CGVHINAGPE IGVASTKAYT SQFISLVMFG LMMSEDRISL QNRRQEIIRG LRSLPELIKE VLSLEEKIHD LALELYTQRS LLVMGRGYNY ATCLEGALKI KEITYMHSEG ILAGELKHGP LALIDKQMPV IMVIMKDPCF AKCQNALQQV TARQGRPIIL CSKDDTESSK FAYKTIELPH TVDCLQGILS VIPLQLLSFH LAVLRGYDVD FPRNLAKSVT VE
Research Areas
Citations (0)

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GFPT2 controls the flux of glucose into the hexosamine pathway. This protein most likely involved in regulating the availability of precursors for N-and O-linked glycosylation of proteins.


Edwards,T.L.,, Ann. Hum. Genet. 74 (2), 97-109 (2010)
Prasad,P.,, BMC Med. Genet. 11, 52 (2010)
Srinivasan,V.,, Clin. Biochem. 40 (13-14), 952-957 (2007)

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$ 350.00
$ 117.00
Cat# AP9282c
Availability: In Stock
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