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HSD17B3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P37058 |
|---|
| Gene ID | 3293 |
|---|---|
| Other Names | Testosterone 17-beta-dehydrogenase 3, 17-beta-hydroxysteroid dehydrogenase type 3, 17-beta-HSD 3, Testicular 17-beta-hydroxysteroid dehydrogenase, HSD17B3, EDH17B3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HSD17B3 (HGNC:5212) |
|---|---|
| Synonyms | EDH17B3, SDR12C2 |
| Function | Catalyzes the conversion of 17-oxosteroids to 17beta- hydroxysteroids (PubMed:8075637, PubMed:16216911, PubMed:27927697, PubMed:26545797). Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:27927697, PubMed:26545797). Testosterone is the key androgen driving male development and function (PubMed:8075637). Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed:16216911). Can reduce 11-ketoandrostenedione as well as 11beta- hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697). |
| Cellular Location | Endoplasmic reticulum |
| Tissue Location | Testis.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
References
Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010) : Sata, F., et al. J Sex Med (2010) In press : Ahn, J., et al. Hum. Mol. Genet. 18(19):3749-3757(2009) Chakrabarti, B., et al. Autism Res 2(3):157-177(2009) Beuten, J., et al. Cancer Epidemiol. Biomarkers Prev. 18(6):1869-1880(2009) Andersson, S., et al. J. Clin. Endocrinol. Metab. 81(1):130-136(1996)
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