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CLDN4 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14493
Additional Information
Gene ID 1364
Other Names Claudin-4, Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor, Williams-Beuren syndrome chromosomal region 8 protein, CLDN4, CPER, CPETR1, WBSCR8
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLDN4 {ECO:0000303|PubMed:35773259, ECO:0000312|HGNC:HGNC:2046}
Function Can associate with other claudins to regulate tight junction structural and functional strand dynamics (PubMed:35773259, PubMed:36008380). May coassemble with CLDN8 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). May integrate into CLDN3 strands to modulate localized tight junction barrier properties (PubMed:35773259, PubMed:36008380). May disrupt strand assembly of channel-forming CLDN2 and CLDN15 and inhibit cation conductance (PubMed:35773259, PubMed:36008380). Cannot form tight junction strands on its own (PubMed:35773259, PubMed:36008380).
Cellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)
citation

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Background

CLDN4 is an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life.

References

Papageorgis, P., et al. Cancer Res. 70(3):968-978(2010)Kimura, J., et al. J. Biol. Chem. 285(1):401-408(2010)Robertson, S.L., et al. Infect. Immun. 78(1):505-517(2010)Seckin, Y., et al. Acta Gastroenterol. Belg. 72(4):407-412(2009)

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$ 277.78
Cat# BP9615b
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