|Other Names||Diacylglycerol O-acyltransferase 2, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, Diglyceride acyltransferase 2, DGAT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1- monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet. Cytoplasm, perinuclear region|
|Tissue Location||Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.|
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Provided below are standard protocols that you may find useful for product applications.
Acyl-CoA:diacylglycerol acyltransferase, or DGAT (EC 188.8.131.52), is responsible for the synthesis of triglycerides. It catalyzes a reaction in which diacylglycerol is covalently joined to long chain fatty acyl-CoAs.
# Kantartzis, K., et al. Clin. Sci. 116(6):531-537(2009)# Stone, S.J., et al. J. Biol. Chem. 284(8):5352-5361(2009)# Yen, C.L., et al. J. Lipid Res. 49(11):2283-2301(2008)# Levin, M.C., et al. Am. J. Physiol. Endocrinol. Metab. 293 (6), E1772-E1781 (2007) # Payne, V.A., et al. J. Biol. Chem. 282(29):21005-21014(2007)# Yamada, S., et al. Oncogene 23(35):5901-5911(2004)# Wakimoto, K., et al. Biochem. Biophys. Res. Commun. 310(2):296-302(2003)
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