|Other Names||Probable lysosomal cobalamin transporter, HDAg-L-interacting protein NESI, LMBR1 domain-containing protein 1, Nuclear export signal-interacting protein, LMBRD1, C6orf209, NESI|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951). Targets ABCD4 transporter from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal transporter ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791).|
|Cellular Location||Lysosome membrane; Multi-pass membrane protein|
|Tissue Location||Isoform 3 is expressed in liver.|
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Provided below are standard protocols that you may find useful for product applications.
LMBD1 is a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus.
Rutsch, F., et al. Nat. Genet. 41(2):234-239(2009)Wang, Y.H., et al. J. Virol. 79(13):8113-8120(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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