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IL-4, murine recombinant protein
BCGF,BCDF, B cell stimulating factor, BSF-1,Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetra
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P07750 |
|---|---|
| Calculated MW | 13.5 kDa |
| Gene ID | 16189 |
|---|---|
| Gene Symbol | IL4 |
| Other Names | BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra, |
| Gene Source | Mouse |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | <.2.0 ng/ml |
| Target/Specificity | IL-4 |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized with no additives. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.
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