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TDGF1, human recombinant protein

CRIPTO1, CRIPTO-1, CRGF, Teratocarcinoma-Derived Growth Factor 1, TDGF1, CR1.

Product info
Primary Accession P13385
Calculated MW 17.4 kDa
Additional Info
Gene ID 6997
Gene Symbol TDGF1
Other Names CRIPTO1, CRIPTO-1, CRGF, Teratocarcinoma-Derived Growth Factor 1, TDGF1, CR1.
Gene Source Human
Source Human cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence A DNA sequence encoding the human TDGF1 (AAH22393.1) (Met 1 - Thr 172) with a C-terminal polyhistidine tag was expressed.
Target/Specificity TDGF1
Application Notes Reconstitute in sterile PBS
Format Lyophilized protein
Storage -70°C; Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
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Teratocarcinoma-derived growth factor 1, also known as epidermal growth factor-like cripto protein CR1, CRGF, and TDGF1, is a cell membrane which contains one EGF-like domain. In humans, TDGF1 is highly expressed in germ cell tumors and in colon and mammary carcinomas. TDGF1 is a member of the epidermal growth factor-cripto FRL1 cryptic protein family and is involved in the activation of several different signaling pathways during embryonic development and cellular transformation. TDGF1 regulates the activation of several signaling pathways and controls cellular transformation in embryonic status. Patients with high TDGF1 expression were statistically susceptible to a recurrence of the disease, and showed poorer disease-free survival than those with low expression. TDGF1 is a predictive marker for metachronous metastasis in colorectal cancer (CRC) patients. It is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 plays a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

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$ 225.00
$ 795.00
$ 8,500.00
Cat# PBV10231r-10
Availability: 5-7days
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