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Mechanism of Notch intracellular signalling. The key transducer of the Notchsignalling pathway is a DNAbinding protein, CSL (CBF1, Su(H) and LAG1). After binding to a Delta ligand, the Notch receptor undergoes a series of proteolytic events near the cell surface, including the S2-cleavage mediated by protease ADAM10 or TNFalpha converting enzyme (TACE or ADAM17), followed by the S3-cleavage mediated by the gamma-secretase enzyme complex, resulting in the release of the Notch intracellular domain (NICD), which then translocates to the cell nucleus. Once in the nucleus, NICD interacts with CSL family of transcription factors, helping to convert the transcriptional co-repressor (Co-R) complex into an activator complex, and thus induce the expression of a panel of target genes.

Confocal immunofluorescent analysis of CBF1(N-term) Antibody #AP17401a on Hela cell. 0.02 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG. FITC emits green fluorescence. DAPI was used to stain the cell nucleus (blue). F-actin filaments have been labeled with phalloidin (red). Immunoreactivity for CBF1 is localized in the nucleus.

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Immunity Source (Host)
Available staus
CBF1 ()