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The ErbB2/Neu receptor, also named HER2, belongs to the EGFR (epidermal growth factor receptor)/ ErbB1/HER1 receptor tyrosine kinase (RTK) subfamily, having two additional members, ErbB3/HER3 and ErbB4/HER4 receptors. HER2 plays an important role in the development of certain human cancers by activating MAPK and PI3K pathway. Down-regulation of RTK activity plays an essential role in coordinating and controlling cellular growth/differentiation. Ca2+/ calmodulin dependent kinase II (CaM kinase II)- mediated phosphorylation of threonine 1172 (T1172) in the cytoplasmic tail and inhibits HER2 activity.

Fluorescent image of MCF-7 cells stained with HER2 Antibody # AP3781h. MCF-7 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min). Cells were then incubated with HER2 Primary Antibody # AP3781h (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Nuclei were counterstained with Hoechst 33342 (blue) (10 μg/ml, 5 min). Phospho-HER2 immunoreactivity is localized to plasma memrane of MCF-7 cells.

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PHER2 ()