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> home > Products > Primary Antibodies > Antibody Collections > Cystine-knot cytokines > Anti-IL17E Picoband Antibody
Anti-IL17E Picoband Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H293 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for IL17E detection. Tested with WB, ELISA(Cap) in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 64806 |
|---|---|
| Other Names | Interleukin-25, IL-25, Interleukin-17E, IL-17E, IL25, IL17E |
| Calculated MW | 20330 Da |
| Application Details | Western blot, 0.1-0.5 µg/ml ELISA(Cap), 0.1-0.5 µg/ml |
| Subcellular Localization | Secreted. |
| Tissue Specificity | Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea. |
| Contents | Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Immunogen | E. coli-derived human IL17E recombinant protein (Position: Y33-G177). |
| Cross Reactivity | No cross reactivity with other proteins. |
| Storage | At -20˚C; for one year. After r˚Constitution, at 4˚C; for one month. It˚Can also be aliquotted and stored frozen at -20˚C; for a longer time. Avoid repeated freezing and thawing. |
| Name | IL25 |
|---|---|
| Synonyms | IL17E |
| Function | Cytokine produced by various cells such as eosinophils, T- helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production (PubMed:15860795, PubMed:25821217). Promotes and augments T- helper type 2 responses locally or systemically (PubMed:25821217). Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction (By similarity). In turn, stimulates the JAK2- STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13 (PubMed:25821217). Induces also the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways (PubMed:15860795). Inhibits the differentiation of T-helper (Th17) cells via the production of IL4, IL5 and IL13 (PubMed:11754819). |
| Cellular Location | Secreted. |
| Tissue Location | Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea |
Research Areas
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$ 370.00
Cat# ABO10305
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