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Anti-Filensin Antibody (Monoclonal, FIL-7B10)
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- BACKGROUND
Application 
| WB, IHC-F |
|---|---|
| Primary Accession | Q02435 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Filensin, beaded filament structural protein 1, filensin (BFSP1) detection. Tested with WB, IHC-F in Human;bovine. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 25394 |
|---|---|
| Other Names | Filensin, Beaded filament structural protein 1, Lens fiber cell beaded-filament structural protein CP 94, CP94, Bfsp1 |
| Calculated MW | 68038 MW KDa |
| Application Details | Immunohistochemistry(Frozen Section), 2-4 µg/ml, Human, bovine, - Western blot, 1-2 µg/ml, Human, bovine |
| Subcellular Localization | Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Detected adjacent to the cell membrane. . |
| Tissue Specificity | Detected in eye lens. . |
| Protein Name | Filensin |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | FIL-7B10 |
| Immunogen | Human and bovine lens filament enriched fraction(plasma membrane-cytoskeleton complex). |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the intermediate filament family. |
| Name | Bfsp1 |
|---|---|
| Function | Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Involved in altering the calcium regulation of MIP water permeability (By similarity). |
| Cellular Location | Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q06002}; Cytoplasmic side {ECO:0000250|UniProtKB:Q06002}. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q06002}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q06002} |
| Tissue Location | Expressed in the deep and shallow cortices of the retina lens (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Filensin, also known as beaded filament structure protein 1, have two major component BFSP1 and BESP2. Filensin gene is mapped at 20p12.1-p11.23. The sequence of the predicted 665-amino acid human protein is 62% and 50% identical to those of bovine and chicken filensin, respectively. However, it has less than 26% identity to other members of the intermediate filament(IF) family.
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