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Anti-Spectrin(Alpha And Beta) Antibody (Monoclonal, SB-SP1)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q6XDA0 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Spectrin(alpha and beta), spectrin, alpha, erythrocytic 1 (elliptocytosis 2); spectrin, beta, erythrocytic (SPTA1; SPTB ) detection. Tested with WB in Human. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Calculated MW | 246329 MW KDa |
|---|---|
| Application Details | Western blot, 2-4 µg/ml, Human |
| Subcellular Localization | SPTA1: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex.|Spta1: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex.|SPTB: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex.|Sptb: Cytoplasm, cytoskeleton. Cytoplasm, cellcortex. |
| Protein Name | Spectrin alpha chain, erythrocytic 1; Spectrin beta chain, erythrocytic |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | SB-SP1 |
| Immunogen | Human erythrocyte spectrin. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the spectrin family. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Spectrin, the predominant component of the membrane skeleton of the red cell, is essential in determining the properties of the membrane including its shape and deformability. It consists of 2 nonidentical subunits, alpha and beta. Spectrin is present in the red cell membrane in a tetrameric or possibly higher polymeric form through head-to-head self-association of heterodimers that are linked by actin polymers and protein 4.1 to form a 2-dimensional network. Non-erythroid spectrin gene is mapped to human chromosome 2. Spectrin mutations cause spinocerebellar ataxia type 5.
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