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Anti-Synaptophysin Antibody (Monoclonal, SVP-38)
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Application 
| WB, IHC-P, IHC-F |
|---|---|
| Primary Accession | P07825 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Synaptophysin, synaptophysin (SYP) detection. Tested with WB, IHC-P, IHC-F in Human;Rat. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 24804 |
|---|---|
| Other Names | Synaptophysin, Major synaptic vesicle protein p38, Syp |
| Calculated MW | 33311 MW KDa |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 1-2 µg/ml, Human, rat, By Heat Immunohistochemistry(Frozen Section), 1-2 µg/ml, Human, rat, - Western blot, 0.5-1 µg/ml, Human, rat |
| Subcellular Localization | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. |
| Tissue Specificity | Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. |
| Protein Name | Synaptophysin |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | SVP-38 |
| Immunogen | Rat retina synaptosome. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the synaptophysin/synaptobrevin family. |
| Name | Syp |
|---|---|
| Function | Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q62277}; Multi-pass membrane protein. Synapse, synaptosome {ECO:0000250|UniProtKB:P08247} |
| Tissue Location | Expressed in the brain with expression in the cerebrum and the cerebellum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptophysin(SYP) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells. Ozcelik et al.(1990) concluded that the gene has 7 exons distributed over about 20 kb. SYP mapped the SYP locus to Xp11.23-p11.22. Regionalization of the gene on the X chromosome was also done with hamster/human hybrid cells in which various portions of the human X chromosome were present.
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