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Anti-Sonic Hedgehog Antibody

     
  • WB - Anti-Sonic Hedgehog Antibody ABO10556
    Anti-Sonic Hedgehog antibody, ABO10556, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Intestine Tissue LysateLane 3: HELA Cell LysateLane 4: A549 Cell LysateLane 5: SMMC Cell LysateLane 6: MM231 Cell Lysate
    detail
  • IHC - Anti-Sonic Hedgehog Antibody ABO10556
    Anti-Sonic Hedgehog antibody, ABO10556, IHC(P)IHC(P): Rat Brain Tissue
    detail
  • IHC - Anti-Sonic Hedgehog Antibody ABO10556
    Anti-Sonic Hedgehog antibody, ABO10556, IHC(P)IHC(P): Human Mammary Tissue
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q15465
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Sonic hedgehog protein(SHH) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 6469
Other Names Sonic hedgehog protein, SHH, HHG-1, Sonic hedgehog protein N-product, Sonic hedgehog protein C-product, SHH
Calculated MW 49607 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Sonic hedgehog protein C-product: Secreted, extracellular space . The C-terminal peptide diffuses from the cell. .
Tissue Specificity Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.
Protein Name Sonic hedgehog protein
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human Sonic Hedgehog(203-218aa ATVHLEQGGTKLVKDL), identical to the related rat and mouse sequences.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the hedgehog family.
Protein Information
Name SHH (HGNC:10848)
Function [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
Cellular Location [Sonic hedgehog protein]: Endoplasmic reticulum membrane. Golgi apparatus membrane. Secreted Note=Co-localizes with HHAT in the ER and Golgi membrane
Research Areas
Citations (0)
citation

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Background

The mouse, chicken, and zebrafish Shh homologs are highly conserved. SHH expression was not detected in adult tissues examined. However, it was expressed in fetal intestine, liver, lung, and kidney. SHH gene is mapped to 7q. SHH mutations are not a frequent cause of isolated oral clefts.

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$ 280.00
Cat# ABO10556
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