Anti-Connexin 37/GJA4 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
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Primary Accession | P35212 |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Clonality | Polyclonal |
Format | Lyophilized |
Description | Rabbit IgG polyclonal antibody for Gap junction alpha-4 protein(GJA4) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat. |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene ID | 2701 |
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Other Names | Gap junction alpha-4 protein, Connexin-37, Cx37, GJA4 |
Calculated MW | 37414 MW KDa |
Application Details | Immunocytochemistry , 0.5-1 µg/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat |
Subcellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. |
Tissue Specificity | Expressed in multiple organs and tissues, including heart, uterus, ovary, and blood vessel endothelium. |
Protein Name | Gap junction alpha-4 protein |
Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human Connexin 37(3-17aa DWGFLEKLLDQVQEH), identical to the related mouse and rat sequences. |
Purification | Immunogen affinity purified. |
Cross Reactivity | No cross reactivity with other proteins |
Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
Name | GJA4 |
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Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction |
Tissue Location | Expressed in multiple organs and tissues, including heart, uterus, ovary, and blood vessel endothelium |
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Background
Gap junction alpha-4 protein(GJA4), also called CX37 is a protein that in humans is encoded by the GJA4 gene. This gene is mapped to 1p34.3. This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. CX37 had been shown to reflect the stage and maturity of luteinized follicles in animal studies.
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