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Anti-IL-16 Antibody

     
  • WB - Anti-IL-16 Antibody ABO11929
    Anti- IL-16 antibody, ABO11929, Western blottingAll lanes: Anti IL-16 (ABO11929) at 0.5ug/mlWB: Recombinant Human IL-16 Protein 0.5ngPredicted bind size: 17KDObserved bind size: 17KD
    detail
  • IHC - Anti-IL-16 Antibody ABO11929
    Anti- IL-16 antibody, ABO11929, IHC(P)IHC(P): Human Tonsil Tissue
    detail
  • ICC - Anti-IL-16 Antibody ABO11929
    Anti- IL-16 antibody, ABO11929, ICCICC: Human Cord Blood
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, E
Primary Accession Q14005
Host Rabbit
Reactivity Human
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Pro-interleukin-16(IL16) detection. Tested with WB, IHC-P, ICC, ELISA in Human.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 3603
Other Names Pro-interleukin-16, Interleukin-16, IL-16, Lymphocyte chemoattractant factor, LCF, IL16
Calculated MW 141752 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat

Immunocytochemistry , 0.5-1 µg/ml, Human, -
Western blot, 0.1-0.5 µg/ml, Human

ELISA, 0.1-0.5 µg/ml, Human
Subcellular Localization Interleukin-16: Secreted.
Tissue Specificity Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.
Protein Name Pro-interleukin-16
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human IL-16 recombinant protein (Position: S1212-S1332). Human IL-16 shares 86% amino acid (aa) sequence identity with mouse IL-16.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Contains 4 PDZ (DHR) domains.
Protein Information
Name IL16
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Cellular Location [Interleukin-16]: Secreted. [Isoform 3]: Cytoplasm. Nucleus.
Tissue Location [Isoform 3]: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation
Research Areas
Citations (0)
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Background

Interleukin 16 (IL-16) is a cytokine that released by a variety of cells (including lymphocytes and some epithelial cells) that has been characterized as a chemoattractant for certain immune cells expressing the cell surface molecule CD4. It is mapped to 15q25.1. IL-16 was originally described as a factor that could attract activated T cells in humans. It was previously called lymphocyte chemoattractant factor (LCF), and the augmentation of IL16 stimulation by CCR5 plays a role in regulation of Th1 cell recruitment and activation at sites of inflammation.

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$ 280.00
Cat# ABO11929
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