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> home > Products > Primary Antibodies > Signal Transduction > Anti-L1CAM Rabbit Monoclonal Antibody
Anti-L1CAM Rabbit Monoclonal Antibody
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Application 
| WB, IHC |
|---|---|
| Primary Accession | P32004 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-L1CAM Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human. |
| Gene ID | 3897 |
|---|---|
| Other Names | Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5 |
| Calculated MW | 140003 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 |
| Subcellular Localization | Cell membrane ; Single-pass type I membrane protein. Cell projection, growth cone. Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AAFD-12 |
| Immunogen | A synthesized peptide derived from human L1CAM |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | L1CAM |
|---|---|
| Synonyms | CAML1, MIC5 |
| Function | Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q05695}. Cell projection, axon. Cell projection, dendrite Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658) {ECO:0000250|UniProtKB:Q05695, ECO:0000269|PubMed:20621658} |
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Application Protocols
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$ 370.00
Cat# ABO13771
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