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> home > Products > Primary Antibodies > Signal Transduction > Anti-INPP4B/Type Ii 4 Phosphatase Rabbit Monoclonal Antibody
Anti-INPP4B/Type Ii 4 Phosphatase Rabbit Monoclonal Antibody
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Application 
| WB, IHC, FC |
|---|---|
| Primary Accession | O15327 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-INPP4B/Type Ii 4 Phosphatase Rabbit Monoclonal Antibody . Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 8821 |
|---|---|
| Other Names | Inositol polyphosphate 4-phosphatase type II, Type II inositol 3, 4-bisphosphate 4-phosphatase, 3.1.3.66, INPP4B |
| Calculated MW | 104738 MW KDa |
| Application Details | WB 1:1000-1:2000 IHC 1:50-1:200 FC 1:50 |
| Tissue Specificity | Widely expressed with highest levels occurring in the skeletal muscle and heart.. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: GDO-9 |
| Immunogen | A synthesized peptide derived from human INPP4B |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | INPP4B |
|---|---|
| Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). |
| Tissue Location | Widely expressed with highest levels occurring in the skeletal muscle and heart. |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO13843
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