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Anti-HDAC10 Rabbit Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IF, ICC, IP |
|---|---|
| Primary Accession | Q969S8 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-HDAC10 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse. |
| Gene ID | 83933 |
|---|---|
| Other Names | Polyamine deacetylase HDAC10, 3.5.1.48, 3.5.1.62, Histone deacetylase 10, HD10, HDAC10 |
| Calculated MW | 71445 MW KDa |
| Application Details | WB 1:1000-1:2000 ICC/IF 1:50-1:200 IP 1:50 |
| Subcellular Localization | Cytoplasm. Nucleus. Excluded from the nucleoli. |
| Tissue Specificity | Ubiquitous. High expression in liver, spleen, pancreas and kidney. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: HEO-8 |
| Immunogen | A synthesized peptide derived from human HDAC10 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | HDAC10 |
|---|---|
| Function | Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome- lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). |
| Cellular Location | Cytoplasm. Nucleus Note=Excluded from nucleoli. |
| Tissue Location | Widely expressed with high levels in liver and kidney. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO13848
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