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Anti-Human IgM IGHM Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IP |
|---|---|
| Primary Accession | P01871 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Human IgM IGHM Rabbit Monoclonal Antibody . Tested in WB, IHC, IP applications. This antibody reacts with Human. |
| Other Names | Immunoglobulin heavy constant mu {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.14}, Ig mu chain C region, Ig mu chain C region BOT, Ig mu chain C region GAL, Ig mu chain C region OU, IGHM {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.14} |
|---|---|
| Calculated MW | 49307 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 IP 1:50 |
| Subcellular Localization | Isoform 1: Secreted. During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AOCG-9 |
| Immunogen | A synthesized peptide derived from human Human IgM |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | IGHM {ECO:0000303|PubMed:11340299, ECO:0000303|Ref.14} |
|---|---|
| Function | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins- secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). |
| Cellular Location | [Isoform 1]: Secreted. Note=During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM. |
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO13999
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