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> home > Products > Primary Antibodies > Signal Transduction > Anti-Catenin gamma JUP Rabbit Monoclonal Antibody
Anti-Catenin gamma JUP Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC, FC |
|---|---|
| Primary Accession | P14923 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Catenin gamma JUP Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 3728 |
|---|---|
| Other Names | Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP (HGNC:6207) |
| Calculated MW | 81745 MW KDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200 FC 1:50 |
| Subcellular Localization | Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cytoplasmic in a soluble and membrane-associated form. |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AOBD-10 |
| Immunogen | A synthesized peptide derived from human Catenin gamma |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | JUP (HGNC:6207) |
|---|---|
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). |
| Cellular Location | Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF7}. Cell junction {ECO:0000250|UniProtKB:Q9PVF7}. Nucleus {ECO:0000250|UniProtKB:Q9PVF7} Note=Cytoplasmic in a soluble and membrane-associated form. Colocalizes with DSG4 at desmosomes (PubMed:21495994) |
| Tissue Location | Expressed in the heart (at protein level). |
Research Areas
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Application Protocols
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$ 370.00
Cat# ABO14166
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