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Anti-KAT9 / Elp3 Rabbit Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, ICC, IP |
|---|---|
| Primary Accession | Q9H9T3 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-KAT9 / Elp3 Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 55140 |
|---|---|
| Other Names | Elongator complex protein 3, hELP3, 2.3.1.311, ELP3 {ECO:0000303|PubMed:15902492, ECO:0000312|HGNC:HGNC:20696} |
| Calculated MW | 62259 Da |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 IP 1:50 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: ADAF-5 |
| Immunogen | A synthesized peptide derived from human KAT9 / Elp3. |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | ELP3 {ECO:0000303|PubMed:15902492, ECO:0000312|HGNC:HGNC:20696} |
|---|---|
| Function | Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5- methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). |
| Cellular Location | Cytoplasm. Nucleus [Isoform 2]: Cytoplasm. Nucleus |
| Tissue Location | Expressed in the cerebellum and spinal motor neurons. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO14503
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