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Anti-PERP Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IF, ICC |
|---|---|
| Primary Accession | Q96FX8 |
| Host | Rabbit |
| Isotype | Rabbit IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-PERP Monoclonal Antibody . Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 64065 |
|---|---|
| Other Names | p53 apoptosis effector related to PMP-22 {ECO:0000312|HGNC:HGNC:17637}, Keratinocyte-associated protein 1, KCP-1, P53-induced protein PIGPC1 {ECO:0000303|Ref.3}, Transmembrane protein THW, PERP (HGNC:17637) |
| Calculated MW | 21386 Da |
| Application Details | WB 1:500-1:2000 ICC/IF 1:50-1:200 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: AFDD-16 |
| Immunogen | A synthesized peptide derived from human PERP |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | PERP (HGNC:17637) |
|---|---|
| Function | Component of intercellular desmosome junctions (By similarity). Plays a role in stratified epithelial integrity and cell- cell adhesion by promoting desmosome assembly (By similarity). Thereby plays a role in barrier function of the skin against infection (By similarity). Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions (By similarity). Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis (By similarity). May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4 (By similarity). Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling (By similarity). Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8 (PubMed:25486861). Required for neutrophil transepithelial migration in response to S.typhimurium infection (PubMed:25486861). May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived shear stress (By similarity). |
| Cellular Location | Cell junction, desmosome {ECO:0000250|UniProtKB:Q9JK95}. Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane (PubMed:31898316). Clusters in a punctate pattern throughout the epithelial cytoplasm, in response to S.typhimurium infection (PubMed:25486861). {ECO:0000250|UniProtKB:Q9JK95, ECO:0000269|PubMed:25486861, ECO:0000269|PubMed:31898316} |
| Tissue Location | Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts. May translocate to the intestinal apical epithelial cell surface via sipA and sctB1/sipC- promoted exocytic translocation following infection by S. Typhimurium (PubMed:25486861, PubMed:27078059). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO14730
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