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Anti-EDNRB Antibody Picoband™ (monoclonal, 15C3)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P24530 |
| Host | Mouse |
| Isotype | Mouse IgG2b |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Anti-EDNRB Antibody Picoband™ (monoclonal, 15C3) . Tested in WB applications. This antibody reacts with Human. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500 µg/ml. |
| Gene ID | 1910 |
|---|---|
| Other Names | Endothelin receptor type B, ET-B, ET-BR, Endothelin receptor non-selective type, EDNRB (HGNC:3180), ETRB |
| Calculated MW | 45 kDa |
| Application Details | Western blot, 0.1-0.5 µg/ml |
| Subcellular Localization | Cell membrane. Multi-pass membrane protein. |
| Tissue Specificity | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. |
| Contents | Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Clone Names | Clone: 15C3 |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human EDNRB, different from the related mouse and rat sequences by one amino acid. |
| Cross Reactivity | No cross-reactivity with other proteins. |
| Storage | Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles. |
| Name | EDNRB (HGNC:3180) |
|---|---|
| Synonyms | ETRB |
| Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=internalized after activation by endothelins. |
| Tissue Location | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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