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> home > Products > Primary Antibodies > Antibody Collections > Loading Control > Anti-beta Actin Mouse Monoclonal Antibody
Anti-beta Actin Mouse Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | P60709 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Rat, Human, Mouse, Rabbit, Chicken |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-beta Actin Mouse Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat, Chicken, Rabbit. |
| Gene ID | 60 |
|---|---|
| Other Names | Actin, cytoplasmic 1, 3.6.4.-, Beta-actin, Actin, cytoplasmic 1, N-terminally processed, ACTB |
| Calculated MW | 42 kDa |
| Application Details | WB 1:3000-1:10000 IHC 1:100-1:200 ICC/IF 1:100-1:200 |
| Contents | Mouse IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 17A10 |
| Immunogen | A synthesized peptide derived from human beta Actin |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | ACTB |
|---|---|
| Function | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:25255767, PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F- actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (PubMed:39321809, PubMed:38609661). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton. Nucleus Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 154.00
Cat# ABO15135
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