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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-Frizzled 9 / CD349 Rabbit Monoclonal Antibody
Anti-Frizzled 9 / CD349 Rabbit Monoclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | O00144 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-Frizzled 9 / CD349 Rabbit Monoclonal Antibody . Tested in WB application. This antibody reacts with Human, Mouse, Rat. |
| Gene ID | 8326 |
|---|---|
| Other Names | Frizzled-9, Fz-9, hFz9, FzE6, CD349, FZD9, FZD3 |
| Calculated MW | 64466 Da |
| Application Details | WB 1:500-1:2000 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 19F62 |
| Immunogen | A synthesized peptide derived from human Frizzled 9 / CD349 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | FZD9 |
|---|---|
| Synonyms | FZD3 |
| Function | Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta- catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9R216}; Multi-pass membrane protein. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8} |
| Tissue Location | Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850). |
Research Areas
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$ 370.00
Cat# ABO15386
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