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Anti-CLSTN1 Rabbit Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | O94985 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-CLSTN1 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse. |
| Gene ID | 22883 |
|---|---|
| Other Names | Calsyntenin-1, Alcadein-alpha, Alc-alpha, Alzheimer-related cadherin-like protein, Non-classical cadherin XB31alpha, Soluble Alc-alpha, SAlc-alpha, CTF1-alpha, C-terminal fragment 1-alpha, CLSTN1 (HGNC:17447) |
| Calculated MW | 150 kDa |
| Application Details | WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:50-1:200 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 21C89 |
| Immunogen | A synthesized peptide derived from human CLSTN1 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | CLSTN1 (HGNC:17447) |
|---|---|
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:21385839). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cell projection, neuron projection. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses {ECO:0000250|UniProtKB:Q9EPL2} |
| Tissue Location | Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO15613
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