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> home > Products > Primary Antibodies > Signal Transduction > Anti-STK33 Rabbit Monoclonal Antibody
Anti-STK33 Rabbit Monoclonal Antibody
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Application 
| WB, IHC, IF, ICC |
|---|---|
| Primary Accession | Q9BYT3 |
| Host | Rabbit |
| Isotype | IgG |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Liquid |
| Description | Anti-STK33 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human. |
| Gene ID | 65975 |
|---|---|
| Other Names | Serine/threonine-protein kinase 33, 2.7.11.1, STK33 |
| Calculated MW | 58 kDa, 50 kDa |
| Application Details | WB 1:500-1:1000 IHC 1:50-1:200 ICC/IF 1:100-1:500 |
| Contents | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
| Clone Names | Clone: 22S21 |
| Immunogen | A synthesized peptide derived from human STK33 |
| Purification | Affinity-chromatography |
| Storage | Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
| Name | STK33 {ECO:0000303|PubMed:34155512} |
|---|---|
| Function | Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed:37146716, PubMed:38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates vimentin/VIM, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q924X7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q924X7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q924X7}. Note=Colocalizes with the caudal end of the manchette, a transient structure that guides tail elongation in elongating spermatids {ECO:0000250|UniProtKB:Q924X7} |
| Tissue Location | Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 370.00
Cat# ABO15645
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